A one-pot multicomponent coupling/cyclization for natural product herbicide (±)-thaxtomin A.
نویسندگان
چکیده
Herbicide (±)-thaxtomin A has been synthesized in a one-pot process with a 32% isolated yield. A multicomponent coupling reaction was utilized to prepare in situ a dipeptide precursor which then sequentially underwent an alkaline mediated keto-amide cyclization to provide the target molecule. Adjustment of diastereoselectivity was achieved using microwave-induced irradiation. The approach incorporates atom economy and reaction efficiency and allows for facile library development.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 41 شماره
صفحات -
تاریخ انتشار 2014